Mpox frequently asked questions and vaccination information

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Mpox (formerly known as monkeypox) is a rare viral infection, mainly found in parts of Central and East Africa. It’s related to the viruses that cause smallpox and cowpox.

How Mpox Spreads

  • Through close physical contact (e.g. during sex)
  • From person to person
  • Incubation period: 5 to 21 days

Symptoms

  • Fever, headache, muscle and back pain
  • Swollen glands, chills, exhaustion, joint pain
  • A rash appears 1–5 days after the first symptoms and can affect any part of the body

If you have symptoms, contact your local sexual health service by phone.


Mpox Vaccine

Who Can Get It?

The vaccine is offered to people at higher risk, including:

  • Gay, bisexual, and other men who have sex with men (especially those with multiple partners, attend group sex or sex-on-premises venues)
  • Staff at sex-on-premises venues
  • Trans and non-binary people, and some cis women who meet the risk criteria

How Many Doses?

  • Two doses, at least 28 days apart
  • A longer gap between doses gives longer-lasting protection
  • One dose already provides strong protection
  • It takes about 14 days after vaccination to build immunity
  • If you have had two doses of the vaccine already you do not need to be vaccinated again
  • If you have had one dose of the vaccine you can be offered a second dose. It does not matter how long ago the first dose was.

How Effective Is It?

  • Estimated to be 70–80% effective
  • Vaccinated people can get Mpox but symptoms are usually milder

How to Get the Vaccine

  • Available only through specialist sexual health services
  • Since the first vaccine programme when it was widely available it has only been offered in London and the Locala and Northern services in Greater Manchester
  • From August 2025, it is being rolled out at all specialist sexual health services.
  • Usually offered during routine appointments — check your local clinic’s website for details
  • Not all appointments (e.g. STI testing with a healthcare assistant) can include vaccination

Other Vaccines Available at Sexual Health Clinics

Specialist clinics also offer vaccines to protect against certain STIs:

  • Hepatitis A: For gay, bi, and other men who have sex with men, and others at risk
  • Hepatitis B: For at-risk groups including gay, bi and other men who have sex with men, sex workers, people who inject drugs, and those with partners from regions where Hepatitis B is common
  • HPV (Human Papillomavirus): For gay, bi, and other men who have sex with men under 46; protects against cancer and wart causing strains
  • Gonorrhoea Vaccine: This vaccine will be offered to gay, bi and other men who have sex with men who are considered at higher risk of gonorrhoea. This includes people who have had a bacterial STI (like gonorrhoea or chlamydia) in the past 12 months or who report at least 5 sexual partners in the past 3 months.

 

Know the facts

  • Spread through close physical contact (e.g. during sex)
  • Symptoms include a rash, fever, headache, muscle and back pain
  • Two dose vaccine is available on NHS

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